WebAug 3, 1998 · The pseudoknot RNA interacts extensively with both subunits of the HIV-1 RT heterodimer. Upon binding of the RNA, 2600 Å 2 of protein surface are buried (Figure 3B and C). Although the 33 nucleotide pseudoknot RNA is small compared with the 76 nucleotide tRNA Lys3, it covers a large portion of the extended substrate-binding cleft of … WebJan 1, 1997 · An RNA pseudoknot is an essential structural element of the internal ribosomal entry site located within the hepatitis C virus 5′ noncoding region. RNA, 1 …
Fei Liu - Principal Scientist, Molecular Biology & Discovery
WebApr 27, 2024 · SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. WebJun 14, 2005 · RNA pseudoknots have been identified in nearly every organism and comprise functional domains within ribozymes, self-splicing introns, ribonucleoprotein … highest and lowest correlation coefficient
Predicting Model and Algorithm in RNA Folding Structure …
WebThe Flavivirus positive-oriented, single-stranded RNA genome has a length of 10,000 - 11,000 bases. The genus includes human pathogens like Zika virus, West-Nile virus, Dengue virus, Yellow Fever virus and other. [1] The 3' UTR ranges between 400 and 700 nucleotides in length. [2] Its RNA secondary structure is known to be necessary for the ... WebWe are presenting NanoFolder, a method for the prediction of the base pairing of potentially pseudoknotted multistrand RNA nanostructures. We show that the method outperforms … A pseudoknot is a nucleic acid secondary structure containing at least two stem-loop structures in which half of one stem is intercalated between the two halves of another stem. The pseudoknot was first recognized in the turnip yellow mosaic virus in 1982. Pseudoknots fold into knot-shaped three … See more The structural configuration of pseudoknots does not lend itself well to bio-computational detection due to its context-sensitivity or "overlapping" nature. The base pairing in pseudoknots is not well nested; that is, … See more Several important biological processes rely on RNA molecules that form pseudoknots, which are often RNAs with extensive tertiary structure. For example, the pseudoknot region of RNase P is one of the most conserved elements in all of evolution. The See more • Rfam entry for PK-HAV pseudoknot See more Many types of pseudoknots exist, differing by how they cross and how many times they cross. To reflect this difference, pseudoknots are … See more • Long range pseudoknots See more highest and lowest boiling point