Plk1 and fibrosis
WebbSince Plk1 expression is limited to proliferating cells, interference with Plk1 function results in apoptotic cell death in various tumor cells but not in normal cells.6,10,12 Multiple lines of evidences have made Plk1 a promising target for the development of novel anticancer drugs. In fact, several small molecule inhibitors against Plk1 have Webb11 apr. 2024 · UBAP2L ensures proper chromosome segregation during mitosis. UBAP2L-mediated regulation of PLK1 is independent of stress signaling. UBAP2L controls both …
Plk1 and fibrosis
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WebbWe explored the total protein or phosphoprotein expression of CDK1, CCNB1, and PLK1 between primary tumor and normal tissues in COAD. Molecular Docking The canonical SMILES and the 3D structure of DHA were obtained according to our previous study ( 24 ). Webb15 feb. 2024 · Interestingly, the transcription factor FOXM1 has been recently found to play a key role in lung fibrogenesis through the upregulation of profibrotic and prosurvival …
Webb17 sep. 2024 · Excitingly, new molecules that target αv-containing integrins are now entering clinical trials for fibrotic diseases, including idiopathic pulmonary fibrosis (IPF) and nonalcoholic... Webb1 nov. 2024 · PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M …
Webb21 mars 2024 · PLK1 (Polo Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include Gonococcal Keratitis and Polyploidy . Among its related pathways are Loss of Nlp from mitotic centrosomes and EML4 and NUDC in mitotic spindle formation . WebbPLK1 is a well conserved master regulator of cell division in eukaryotic cells, particularly involved in mitosis, where its functions are well understood ( 21, 24 ); less known is its …
WebbPolo-like kinase 1 (Plk1) is an important mitotic kinase that is crucial for entry into mitosis after recovery from DNA damage-induced cell cycle arrest. Plk1 activation is promoted …
WebbIPF, idiopathic pulmonary fibrosis. from publication: Pan-transcriptome-based candidate therapeutic discovery for idiopathic pulmonary fibrosis Background: There are two US Food and Drug ... muay lao federationWebbNational Center for Biotechnology Information how to make text a clickable linkWebbMyofibroblasts promote fibrosis in multiple organs, including the lungs. In this study, we identified PLK1 as a promoter of... Myofibroblasts, Bronchiolitis and Fibrosis ... how to make text appear on screen minecraftWebb5 maj 2003 · A close correlation between mammalian Plk1 expression and carcinogenesis was recently documented. Mammalian Plk1 was found to be overexpressed in various human tumors, including head and neck squamous cell carcinomas, oropharyngeal carcinomas, non-small cell lung cancer, melanomas, and ovarian and endometrial … how to make text animation in powerpointWebb1 nov. 2024 · PLK1 has an indisputable role in cancer as it controls several key transcription factors and promotes cell proliferation, transformation and epithelial-to … muay martial art formWebb1 mars 2016 · Based on METAVIR stage and clinico-biological data of patients, all patients with advanced fibrosis (score > F2) expressed high levels of PLK1 and undetectable levels of SLAMF3. Our results suggest that the expression of SLAMF3 could be considered as a marker of HCC as its expression was inversely correlated to that of PLK1. how to make text appear one by one powerpointWebb15 juni 2024 · Myofibroblasts promote fibrosis in multiple organs, including the lungs. In this study, we identified PLK1 as a promoter of myofibroblast differentiation and … how to make textarea uneditable