Megalin function

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August undefined, 2024

WebMegalin, a 600-kDa scavenger receptor in the renal proximal tubes, is a low-affinity nonspecific receptor for RBP that mediates the endocytosis and transcytosis of … WebThis study examined whether urinary C-megalin reflects renal function or albuminuria in diabetes. Methods: This was a cross-sectional study involving 1576 patients with type 1 …

Megalin, a multi-ligand endocytic receptor, and its participation in ...

Web30 mrt. 2004 · Dent disease is characteristic for the urinary loss of low-molecular-weight proteins and calcium, leading to renal calcification and, in some patients, chronic renal failure. This disorder is caused by loss-of-function mutations in the renal chloride channel gene, CLCN5. The animal model of this disease has demonstrated the possible role of … Web29 aug. 2024 · Megalin, a membrane-associated endocytic receptor, and its related proteins such as cubilin, the neonatal Fc receptor for IgG, and NaPi-IIa are important in receptors … brother india printer software download

LRP2 gene: MedlinePlus Genetics

WebMegalin is a large multifunctional endocytic clearance receptor for circulating proteins that has been implicated in vitamin D uptake and delivery to the kidney for activation to 1,25 (OH)2 D [62]. Knockout of the megalin gene in mice usually is lethal but the few survivors were characterized as having severe rickets [63]. Web26 jan. 2016 · Impairment of megalin function, even in the early stages of diabetes, has been observed in rat animal models as well as in patients [78–80]. Streptozotocin-induced diabetic rats had decreased protein expression of megalin at the apical membrane of proximal convoluted tubule cells. WebNormal reabsorption of glomerular filtrate proteins probably requires recycling of the endocytic receptors megalin (gp330) and cubilin. Both receptors are located on the … brother india support

Urinary megalin deficiency implicates abnormal tubular endocytic ...

Preferential megalin-mediated transcytosis of low-hormonogenic …

Web9 sep. 2024 · The results point to the pro-oncogenic role of the metallothionein-megalin functional axis, which may impact tumor phenotype and behavior. Abstract This study aimed to assess the relationship and possible interactions between metallothioneins (MTs) and megalin (LRP-2) in different grades of oral squamous cell carcinoma (OSCC) and … Web21 mrt. 2024 · The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many … brother induction motor distributorWeb1 apr. 2001 · Megalin serves important functions in calcium homeostasis. As described, megalin mediates proximal tubule endocytosis of the DBP-vitamin D complex, resulting in the renal hydroxylation and activation of vitamin D . In addition, megalin mediates tubular uptake and subsequent lysosomal degradation of PTH . brother indonesia support

"Web14 mrt. 2024 · Megalin is well known for its role in the reabsorption of proteins from the ultrafiltrate. Recent studies suggest that megalin also reabsorbs renin and angiotensinogen. Indeed, without megalin urinary renin and angiotensinogen levels massively increase, and even prorenin becomes detectable in urine. Recent Findings " - Megalin function

Megalin function

Preferential megalin-mediated transcytosis of low-hormonogenic …

Web18 feb. 2024 · The functional role of these SBEs and of the SMADs in the repression of megalin expression induced by TGF-ß1, was deciphered using luciferase activation assays. The concomitant overexpression of transcription factors SMAD2 and SMAD3 caused a significant decrease in megalin promoter activity and also of megalin protein, in the …

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Web1 apr. 2002 · Megalin is involved in the regulation of thyroid-hormone production by the thyroid gland by mediating uptake and transcytosis of thyroglobulin. The endocytic uptake of nephro- and ototoxic drugs,... Web23 mrt. 2024 · Megalin is a 600 kDa single transmembrane protein with a small intracellular tail and a large extracellular domain containing 4 ligand-binding regions, allowing it to bind >40 different ligands, including albumin. 9, 10 Megalin forms a 1:1 complex with the extracellular protein cubilin.

Web23 jun. 2005 · Megalin is a multifunctional endocytic receptor that is expressed in renal proximal tubules and plays critical roles in the renal uptake of various proteins. It was hypothesized that megalin-dependent endocytosis might play a … WebMegalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease. Proximal tubule protein uptake is mediated by 2 receptors, megalin …

Web28 mei 2024 · It is also notable that SELENOP is contained in mothers' milk and has the function to supply Se to offspring . The effective Se transport system of SELENOP is mediated by its receptors, such as apolipoprotein E receptor 2 (ApoER2), megalin, and low-density lipoprotein receptor-related protein 1 (LRP1), which belong to lipoprotein receptors. Web1 mei 2024 · We propose a novel model for albumin retrieval along the PT in which cubilin and megalin receptors have different functions in recovering filtered albumin in …

Web1 jan. 2006 · RAP binds megalin with high affinity within the RER and functions as an intracellular ligand inhibiting the binding of most other ligands to megalin. RAP also binds other members of the LDL receptor family with a similar function. Because RAP specifically inhibits binding to megalin, it serves as an important tool for the study of megalin function.

Web15 mrt. 2024 · Reduction in the functional activity of megalin/cubilin leads to proteinuria, which, if not resolved, can lead to inflammation, fibrosis, kidney injury culminating into cardiovascular diseases, in ... brother indianapolisWebMegalin: A Novel Endocytic Receptor for Prorenin and Renin. Megalin is an endocytic receptor contributing to protein reabsorption. Impaired expression or trafficking of … cargo of doomWeb13 sep. 2024 · There is evolving evidence that megalin is a regulator of the renin-angiotensin system, and contributes to atherosclerosis. This brief review provides … cargo of dreamsWebMegalin, a membrane-associated endocytic receptor, and its related proteins such as cubilin, the neonatal Fc receptor for IgG, and NaPi-IIa are important in receptors … cargo north bayWebMegalin, a member of the low density lipoprotein endocytic receptor family, is expressed on the apical surface of thyroid epithelial cells, directly facing the follicle lumen, where … cargo of 200Web11 jul. 2014 · Megalin plays a particular key role in the proximal tubular uptake of glomerular-filtered albumin and other low-molecular-weight-proteins. Consistent with this function, megalin knockout mice develop low-molecular-weight proteinuria and albuminuria [ … brother indonesia officeWebMegalin is an endocytic receptor responsible for thyroglobulin (Tg) transcytosis, a process that favors hormone release. Accordingly, megalin KO mice have primary … brother indonesia printer