Cisplatin potassium wasting

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August undefined, 2024

Webbular dysfunction with sodium, potassium, and magne-sium wasting. Most patients have a reversible decrease in glomerular filtration, but some have an irreversible de- ... Cisplatin is accumulated by peritubular uptake in both the proximal and … WebMar 1, 2024 · cisplatin cyclosporine duloxetine lithium methotrexate methylphenidate NSAIDs, such as diclofenac, ibuprofen, or indomethacin sucralfate other medications that lower potassium. People taking oral medications for diabetes may need to talk to their doctor about adjusting the dose of their medicine.

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WebCisplatin is known to induce Fanconi syndrome and renal salt wasting (RSW). RSW typically only requires transient normal saline (NS) support. We report a severe RSW case that required 12 liters of 3% saline. A 57-year-old woman with limited stage small cell cancer was admitted for cisplatin (80 mg/m 2) and etoposide (100 mg/m 2) therapy. WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … optic factory

Hypokalemia - Endocrine and Metabolic Disorders - Merck …

WebJul 18, 2024 · Cisplatin may cause hypomagnesemia by downregulating the TRPM6/EGF pathway. Of note, Mg co‐administration mitigates both cisplatin‐induced … Webis an uncommon genetic disorder characterized by renal potassium and sodium wasting, excessive production of renin and aldosterone, and normotension. Gitelman syndrome is caused by loss of function mutations in a thiazide-sensitive ion … WebJul 2, 1992 · Cisplatin has many toxic effects; emesis, impairment of renal function, myelosuppression, peripheral neuropathy, ototoxicity and renal tubular wasting. We used MVP regimen (Mitomycin C, Vp-16, and Cisplatin) in advanced Non-Small Cell Lung Cancer (NSCLC). porthmeor beach fishing

Cisplatin-induced renal salt wasting syndrome - PubMed

Renal salt wasting in patients treated with high-dose cisplatin ...

WebThe urinary potassium excretion of a patient with hypokalemia is lowered to less than 25 mEq/day. 35 A value above this suggests at least a component of renal potassium wasting. Because 24-hour urine collections are often impractical, a spot urine potassium may be performed. WebHyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) or gastrointestinal loss of sodium is sometimes seen during chemotherapy. However, … optic fan on the viewWebDec 13, 2024 · The electrolytes affected are primarily mineral ions, specifically potassium, calcium, magnesium, sodium, and chloride. Fundamentally, like Bartter’s syndrome, Gitelman syndrome is a salt wasting nephropathy. The symptoms and severity of the disorder can vary greatly from one person to another and can range from mild to severe. optic family

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Cisplatin potassium wasting

Potassium Disorders: Hypokalemia and Hyperkalemia AAFP

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin … WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as …

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WebJul 20, 2024 · Since platinum agents are nephrotoxic, emetogenic and diarrheagenic, they have the potential to induce potassium wasting … WebCisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal …

WebCDDP-induced hyponatremia has also occurred in a case of renal salt-wasting syndrome, 4 in patients with nausea/vomiting/anorexia, and when vigorous hydration was administered to prevent nephrotoxicity. 5 It is sometimes difficult to accurately diagnose the cause of hyponatremia because various contributing factors can interact in a complex manner. WebApr 1, 2024 · The patient’s laboratory values on admission He was admitted to the hospital and received a total of 230 mmol of potassium intravenously and by mouth over the next 20 hours, but his serum potassium level increased to only 2.9 mmol/L. Therefore, the nephrology service was consulted to evaluate his refractory hypokalemia.

WebJan 12, 2024 · A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. J Clin … WebClinical implications of potassium depletion Protective effect of potassium Hypokalemia Potassium supplementation strategies: prevention vs repletion Compliance issues and potassium replacement therapy Potassium repletion and the role of magnesium Consensus guidelines for the use of potassium replacement in clinical practice Article …

WebJul 18, 2024 · In fact, Schilsky and colleagues showed that 22 of 29 patients (76%) who received cisplatin for non-seminomatous germ cell tumors developed acute hypomagnesemia; eleven (50%) remained hypomagnesemic for at least 3 years. 83 This long-term effect has been corroborated by other investigators as well. 84, 85

WebAug 16, 2024 · Cisplatin-associated electrolyte dysregulation is a prevalent therapy-related adverse effect. There are numerous electrolyte-supplemented hydration regimens that have been evaluated, however these studies focused on the development of nephrotoxicity. porthmeor beach flatsWebRefractory Potassium Repletion due to Cisplatin-Induced Magnesium Depletion JAMA Internal Medicine JAMA Network • Cisplatin is a common cause of hypomagnesemia … optic eyewear trends 2018 imagesWebOne way your body regulates blood potassium levels is by shifting potassium into and out of cells. When there is a breakdown or destruction of cells, the electrolyte potassium moves from inside of the cell to outside of the cell wall. This shift of potassium outside of the cells causes hyperkalemia. optic fashion clipsWebCisplatin Foscarnet Aminoglycosides: Laxatives/enemas Sodium polystyrene sulfonate: ... Renal potassium wasting is indicated by a 24-hour urine potassium level exceeding 15 to 30 mEq per L. porthmeor beach mapWebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and ... water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. Fed Pract. 2024 December;38(12 ... porthmeor beach holiday accommodationWebApr 7, 2015 · Cisplatin-associated acute kidney injury (AKI) occurred in 8% of the patients. Urine neutrophil gelatinase-associated lipocalin to urine creatinine ratio (NGAL/Cr) and … porthmeor bowls clubWebFeb 5, 2014 · Cisplatin is one of the most potent and valuable chemotherapy agents available, and is used to treat a broad spectrum of malignancies, with cisplatin … porthmeor beach dog friendly