Biologically relevant motifs
WebThis can be achieved by using macrocyclization to constrain peptides into their unique and bioactive conformations. Macrocyclic-based designs of biologically relevant peptides may be informed by the patterns of hydrogen bonding observed in X-ray crystal structures. Covalent surrogates of hydrogen bonds reduce entropy by destabilizing unfolded ... WebSep 6, 2012 · This highlights a caveat in predicting expression from motifs; while we can identify biologically relevant motifs, this type of analysis only suggests a subset of factors that likely bind to a ...
Biologically relevant motifs
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WebNov 1, 2004 · We show that the module cores, the parts with the highest intramodular connectivity, are biologically relevant components of the networks. These constituents correlate only weakly with other levels of organization. ... In the case of the 5' motifs, the statistic measures the number of regulatory motifs common to at least more than half of … WebMay 14, 2024 · Identification of biologically relevant motifs in proteins is a long-standing problem in bioinformatics, especially when considering distantly related proteins where sequence analysis alone becomes increasingly difficult. Here we present a novel approach to identify such motifs in protein three-dimensional structures without depending on se-
WebSep 27, 2024 · Introduction. Biopolymers, such as DNA and protein, perform varying functions based on their primary sequence. Short, repeated sequences, or “motifs” represent functional units within biopolymers that …
WebNov 4, 2005 · The algorithm presented here represents an attempt to extract biologically relevant motifs based on sequence information from large-scale mass spectrometry–based data sets, and is meant to serve ... WebMay 14, 2024 · Identification of biologically relevant motifs in proteins is a long-standing problem in bioinformatics, especially when considering distantly related proteins where …
WebMay 1, 2008 · The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances.
WebJun 1, 2024 · The ability of this method to rapidly synthesize various types of biologically relevant 1,3-dienyl-6-oxy motifs is highlighted in Figs. 6c and 7. The direct applicability of this method was ... chip lydum university of washingtonWeb2 days ago · Network maps for endophenotypes in the human interactome are enriched with disease genes, further supporting the idea that disease genes form biologically relevant clusters in the broader network ... grants for emotional support animalsWebBiological motion is motion that comes from actions of a biological organism. Humans and animals are able to understand those actions through experience, identification, and … chip lynch icbaWebSep 9, 2024 · Crosslinking and immunoprecipitation (CLIP) is a method used to identify in vivo RNA–protein binding sites on a transcriptome-wide scale. With the increasing amounts of available data for RNA-binding proteins (RBPs), it is important to understand to what degree the enriched motifs specify the RNA-binding profiles of RBPs in cells. We … chip lymanWebInteractions between protomers are illustrated on the basis of oligomeric structures of each AAA+ subgroup. The possible role of conserved motifs in the nucleotide binding pocket … chip lynn golfWebMar 11, 2010 · The approach successfully discovers biologically relevant motifs and their intervals of localization in scenarios where the motifs cannot be discovered by general motif finding tools. It is especially useful for discovering multiple co-localized motifs in a set of regulatory sequences, such as those identified by ChIP-Seq. grants for employers of apprenticesWebDownload Table Detailed Overview of Selected Biologically Relevant Motifs from publication: A Novel Algorithm for Enhanced Structural Motif Matching in Proteins As widely discussed in ... chiplun water park